orangeleader.com (Orange, Texas)

July 18, 2013

Study finds no reduction in rate of cardiovascular events from lifestyle intervention program

Special to The Leader
The Orange Leader

HOUSTON — In a study of over 5,000 overweight or obese patients with type 2 diabetes, researchers found that an intensive lifestyle intervention focusing on weight loss did not reduce the rate of cardiovascular events in these patients. The results appear this week in the New England Journal of Medicine.

The intervention, referred to as Look AHEAD, was stopped in September of 2012 on the basis of futility analysis, but did still show some important findings, according to Dr. John Foreyt, professor of medicine at Baylor College of Medicine who led BCM’s study site.

According to Foreyt, although the study did not find significant differences in heart attacks and strokes between the intervention group and control group, it did find that the intervention group had many benefits including:

• Blood sugar control

• HDL

• Blood pressure

• Cholesterol

• Physical function

• Risk of kidney disease

• Risk of diabetes eye disease

• Lower healthcare costs for medications and hospitalizations

• Reduced sleep apnea

• Reduced loss of mobility

• Reductions in urinary incontinence

The study also found that the weight loss in the intervention group led to improved quality of life and reduced risk of developing depressive symptoms.

“Our bottom line is that modest weight loss in individuals with type 2 diabetes will lead to many improvements in health and well• being. Other studies have shown that weight loss can also reduce or delay the development of type 2 diabetes,” said Foreyt. “Look AHEAD will continue to follow the participants to look at longer• term health effects and will provide general health information to all of the study participants.”

The full report is available at http://www.nejm.org/doi/full/10.1056/NEJMoa1212914?query=featured_home.